Glutathione is a tripeptide, and is made from a combination of the following components: Cysteine, Glutamic Acid, and Glycine.

Why is it a part of the Cochran Regimen in treating Cardiovascular/Heart Disease & Parkinson's Disease at this time?

1. It is a very powerful antioxidant that is produced in the liver, where the largest amount of it is kept and stored. Its purpose in the liver is to assist as a co-factor and co-agent in the detoxification of very damaging cellular waste by products, toxins and other harmful components.
2. It assists in the transfer of these toxins into bile salts that are then dumped into your large intestines.
3. It works with, and assists in, proper liver function and cellular operation. It is enhanced when used in conjunction with Lipoic Acid in correcting the required liver synthesis function. We have seen Lipoic Acid and Glutathione work very well together in restoring an increased level of liver capacity.
4. When Glutathione comes in contact with either white or red blood cells (whether the blood is inside the liver or throughout the circulatory system) it has the following biochemical effects:
5.  

   • Because of its powerful antioxidant strength, it acts as guardian, so to speak, in shielding and preventing future or present cellular (White/Red Blood cells) injury.
   • It provides for cellular health by helping to maintain cells in an existing proper state and by repairing partially damaged cells. It helps sustain against cellular deterioration that is occurring in blood cells.
   • Because of its interface with blood cells, when making molecular contact, it will stop, on the spot, the corruptibility of the cell, helping to return the cell to its proper state immediately, so that cells raise to a higher state of soundness and integrity. By the effective exchange of the co-factor relationship, the cell is placed back to the "cellular proper completeness".

6. Glutathione is also needed and used on a regular, on going basis, for correct and proper organ function inside the stomach, small intestines lining and to a lesser amount in the large intestines. It has a very positive effect inside the lining of the lungs where it is also used and consumed.
7. It is needed in cycle for proper carbohydrate metabolism to occur.
8. We use it in treating Cardiovascular disease because of it ability to molecularly cause reactions which bring about the decomposition and disintegration of oxidized fats that are in the blood stream and on the artery walls. Which is one of the major causes of Atherosclerosis.
9. We use it because it is directly related to the many problems of age-related diseases and aging itself. We have seen that it plays a very active role in putting into action a cellular influence that has anti-aging qualities. As we age, our Glutathione levels start declining. The decline starts in the mid-twenties and gets worse the longer you live. The kicker is, that the lower the Glutathione levels drop, the faster, in turn, the acceleration process of aging happens.
10. Because Parkinson's is an age related disease, (under normal conditions) and because of the aging process, that has been going on for the last forty years, Glutathione levels have declined greatly vs. those of a normal 22-year-old. It is this lack of normal levels of Glutathione that helps bring about the defective operation within the nervous system. These problems and symptoms can be any one, or a combination, of the following Neuro-control systems: a) Difficulty maintaining balance. B) Inability to use proper form while walking or running. C) Inability to control hand/arm or feet/leg tremors. D) Lack of hand or leg/eye coordination. E) Other related and indirectly related mental disorders.
11. Glutathione plays an important role in the age related disease process and can correct it. Some may say that it is better to use Cysteine, (a very unstable amino acid) Glutamic acid, and Glycine, supplying the raw materials so that the liver can make Glutathione. They may also advise using N-Acetyl-L-Cysteine. But they miss two very important parts of the total situation: A) There is nobody, anywhere, at or even near their 20 years old level of capabilities and capacity. So giving raw materials in the early, intermediate, or late stages of liver degeneration is just throwing away good amino acid groups that are not going to be able to be used at all. B) By giving Glutathione in proper dose levels, you immediately start the process of getting the liver functioning at more correct levels each and every day it is used over a period of time. It took 40 to 50 years for the patient to deteriorate to this state, but I project, through biochemical and biophysics projections, that recovery would and should occur in one tenth of that time.

Glutathione is an N-terminal glutamate, which is linked to L-Cysteine via a non-a-peptidyl bond, which is required by several different enzymes. Glutathione and the enzyme Glutathione reductase participates in the formation of the correct disulfide bonds of many proteins and polypeptide hormones and participates in the metabolism of xenobiotics.

But the Conjugation reactions, the Eleltrophilic, Hydroxylation of the metabolism and the response to Xenobiotics is an another report.

Best Regards - Tim Cochran

Theorist/Therapeutic Biochemist

"God may forgive you for your sins, but Nature will never forgive you, for sinning against your body!"