PIPERINE

Piperine has been shown to do the following:

1. Dramatically increases the absorption of Selenium, Vitamin B and Beta-Carotene.
2. Enable more efficient absorption of needed or targeted nutrients during the digestive process.
3. Supports and assists the body’s natural thermogenic activities.

Regardless of the intake of nutritional foods and supplements, if the small intestines cannot effectively absorb the nutrients, then medical benefits are lost. As the body ages, the intestines become less and less efficient in their absorption capacity.

Oddly enough, a chemical compound that is found in common house spice "Black Pepper", - Piperine Extract, comes from the fruit of the black pepper plant piper nigrum and piper long has been shown to significantly enhance the absorption rate of nutrients.

Piperine, is a patent-pending form of "Bioperine" which has been proved in medical trials and research to enhance the body’s natural thermogenic activities. Thermogenesis, the process of generating energy in the cell, enables the body to properly utilize the foods and nutrients taken in daily. It sets the stage for the appropriate activities that lead to digestion and subsequent intestinal absorption. Piperine increases thermal energy sufficiently to "Jump Start" so to say, the operation related to Thermogenesis. This increases the metabolic process that in turn creates a demand for the nutrients necessary for metabolism.

Because black pepper and Piperine are not identical, one having to be processed by several steps in a laboratory, the same effects cannot be achieved by merely increasing ones use of the black pepper spice. Instead, purified Piperine extract is needed to ensure that the bioavailability enhancing properties are utilized for the right and appropriate nutrient absorption levels as when you were younger.

Studies in the United States have measured the dramatic effectiveness of Bioperine and have shown increase in the absorption of Beta-Carotene, Vitamin B6, and Selenium. Selenium and Vitamin B6 levels increased by from thirty (30%) to Forty (40%) percent while Beta-Carotene increased by sixty (60%) percent. More studies are underway to test its effect on other vitamins and minerals.

As a spice, black pepper has a history of safe use for several thousands of years. Piperine also has no known side effects and studies have shown this compound to help make the most of the body’s fuel sources by aiding healthy and proper digestion and nutrient absorption.

Update   Piperine                                                                                                                                                January 30, 1998

Doses usually start out at 15 mg three times per day, this is a starting off dose to see how the patient responds. At this base line dose under normal age related or disease conditions it performs very well. If results are only minimal we will do the following.

For some patients we must increase the dose to 25 to 30 mg three times per day before we get the transfer of medication through the intestinal lining and on to the portal vein in levels that the patient needs to get the results we are looking for. The patient doses are increased slowly until the targeted levels are reached. Normally, in 5 mg increments, spread out three times per day in conjunction with the current amount of Piperine that they are taking. I myself have been taking 10 mg three times per day for going on a couple years now.

Intestinal deterioration and aging is something that most people just never think about, let alone even worry about. But it is a very important part of the Cochran Regimen and Treatment program. It is a problem that we have been studying and working on for years now. What good is the food you eat, if the absorbency rates are only at 5% to 20% of correct or normal capacity? It's a dysfunctional system in urgent need of repair in my mind's eye.

A whole host of toxins, many of then social toxins, such as Alcohol, damages and then ruin's the stomach and intestinal track over the long haul of ones life. Not even considering the normal age related degeneration process. Thus completely breaking down and then stopping the intestinal cellular ability to do what it was designed to do. Break down food, and then transfer the much-needed nutrients through the intestinal barrier and on to the liver for the physiological requirements of properly running a human body.

We can state that Piperine greatly enhances and supports the intestinal absorption. If the intestines can't effectively absorb nutrients, the person's health is damned. There is just little or no hope about the situation. If anyone believes anything else - they are deluded! As the body ages, the intestines become less efficient in their absorption capacity and the ratio's of absorption drop. I have used biochemical physiological models of degeneration factors, but the average deterioration in healthy tissue is about 1 to 2% per year from the age of 25 onward. If you ingest toxins, social or other wise, the rate of destruction to the intestinal track cellular make up will be increased to 3 to 5% per year which equals a noticeably less absorbency rate than the year before. Our projected rates of cellular destruction are verified when Piperine is used in the Cochran Regimen-treatments by the improvements to patient health, which are noticed immediately.

We know the range of absorbency is 30 to 60% based on other medical trials. In our own trials we have seen these numbers increase higher than these numbers. But the dose levels are moderately higher and are kept at those levels for many months or going on years now.

Piperine is an extract that comes from the fruit of the black pepper plant of "Piper Nigrum" and "Piper Longum". Piperine has been shown to significantly enhance and increase the absorption of nutrients into the blood stream.

Piperine increases the body's thermogenic activity, which is directly related to the process of generating energy in the cells. Once Thermogenesis is pointed in the right direction; only then can proper and correct levels of cellular energy be approached, it enables the body to properly utilize the foods, which are eaten, and the nutrient supplements that we are giving to our patients on a daily basis.

It helps set the entry levels, or background stage work, in reaching the normal or required biochemical platform that we are pushing the patient's biochemistry towards. {An earlier biological level.} And in doing do, it assists in setting off a massive biochemical chain reaction which is not only needed but mandatory and required for appropriate molecular cellular activities. This pathway then moves on and leads directly to a much higher level of correct functional digestion and thus subsequently more efficient intestinal absorption ratios and rates of nutrient transfer.

Piperine increases the much needed thermal energy mass (biophysics) on a molecular cellular basis by increasing the energy supply that is now pouring or flooding across the once defective intestinal lining and barrier, of a sick or aged patient; on to the liver with direct operations related to Thermogenesis. This in turn will and does increase the metabolic processes, and that pathway leads to an increased, created demand for additional nutrients and energy, which are necessary for increased and proper efficiency of metabolism. Which is one of the age related problems that have a direct effect in fighting the disease in question.

Piperine and Black pepper, from which Piperine is extracted from, are not the same. The same results can't be achieved by merely increasing the use of black pepper spice in ones diet. If folks believe other wise, and some do, they are just chasing a moving shadow. Because it is chemically impossible for your stomach to break down black pepper and then extract the enzyme that makes Piperine.

We have not seen any negative side effects from the biochemical use of medication levels of Piperine in our on going medical trials that started as far back as September of 1996. There is also a limited antioxidant capability or capacity, but when you are dosing a patient on the Cochran Regimen, with the massive amount of the many different kinds and types of antioxidants that we use, it is really difficult to verify how much of a role it is playing. I'm sure that it assists and helps out, but we use it at the doses we do for the transfer effect and enhancement of capacity and the massive increase in the capabilities of the small intestines and stomach region of the body.

Best Regards - Tim Cochran

 P.O. Box # 9060, Cedarpines Park, California USA 92322·,Fax #(909)338-4010

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