Medical report done in conjunction with Cardiovascular and Parkinson Disease Medical Trials for Dr. Pravin Kini – General Chairman C.F. I. & Dr. Uday Muttane M.D. D.M. – Neurologist P.H.D.

POTASSIUM: A VERY ESSENTIAL MINERAL FOR CARDIOVASCULAR & NEUROLOGICAL FUNCTION:

1. Potassium assists in the regulation of blood pressure throughout the cardiovascular system.
2. When optimal levels Potassium are reached and maintained, Neurological firing of nerve transmission impulse increase in efficiency.
3. By having a patient reach their optimum in take levels, Potassium strengthen and enhances the function of the entire nervous system.
4. Potassium stabilizes and helps lower the hearts rhythm rate. This is due to an increase in correct and proper nerve electrical signals and transmission regulating of the heart muscle.
5. Potassium is required in the biochemical reaction in order for the secretion of hormone actuates.

The body needs sodium, but in excess amounts, inside the cells, becomes a leading cause of cellular tissue destruction. The ingestion of too much Sodium and the response inside the body is a direct cause to much tissue degeneration and is a leading killer. Potassium has the biochemical ability to help and assist in the removal of Sodium out of the body's tissue, on the cellular, molecular level. And in doing so, restore the proper balance of Sodium inside of the body. It is the Potassium ion molecule's ability to enter the cell and then lock on to the Sodium ion, that makes their removal possible. It then escorts it from the cells throughout the blood stream, staging it inside the liver. There it is processed into Bile Salts and then dumped into the large intestines for removal. It is also escorted and processed in the kidneys, and it assists in the reduction of excess body fluid. Please note that we only want to remove excess amounts of Sodium, because together with Potassium, it regulates the amount of body fluid inside your physiological system. Potassium improves and enhances the performance of nerve impulses to the muscles throughout the body.

Please note that we are assisting the Kidneys in reductions of Sodium. The hormone Aldosterone helps regulate the amount of Sodium inside the body at any give time. But as we age, the production of this hormone drops and, as a result, the amount of Sodium is not readily removed from the Kidneys at age 65 as it was at 25. That is why we use Potassium in our medical trials on aged patients with these diseases.

In the Biochemical process, the Sodium levels are removed and lowered, in doing so, the blood pressure drops accordingly. Some doctors advise lower Salt intake to assist in lowering high blood pressure, but we advise normal intake of Sodium and also advise proper level of Potassium ingestion, which solves the problem in a balanced fashion. Once Potassium is absorbed into the blood stream, its positive affects are usually noticeable within 24 to 72 hours after the patient began taking Potassium. In our medical trials we have seen this response with the doses that run from 75 mg to 99mg elemental Potassium taken three times a day. We advise the doses be spread out throughout the day, so that the optimum affect is reached and maintained. That is so the body’s desired biochemical platform level can be reached and then is kept there. We strongly advise Potassium that has been bonded with or chelated with an amino acid. We have seen better absordability, better assimilation into the blood stream with Potassium Gluconate.

Heart pulse abnormalities or irregularities in the patients heart rhythm are usual signs and signals that you are witnessing a potassium deficiency. We have seen potassium have a stabilizing effect on the nerve impulses, which regulate the heart muscle (Papillary Muscle, Ventricles and Chordae Tendinease). It is by potassium interface with the nerve system surrounding the heart region that makes this happen. Heart rhythm becomes once again stable, balanced and then usually the pulse lowers (5 – 10% drop) downward to a level which supports recovery with cardiovascular health improvement to the patient. What we can report is enhancement and improvement of the transmission of electro-biochemical signal impulses of the nervous system. Especially in relationship to stabilizing the heart beat of the cardiovascular patient.

Other points of interest with regards to Potassium: We have notice that it helps in reduction of high cholesterol levels, and that potassium assists in lowering over all cholesterol levels. It also helps in reversing or slowing down the loss of protein in the urine (Proteinuria). Now we believe that this is because of the inter-reactions, which are happening inside the kidneys with the proper ratio of Potassium, Sodium and with several the hormones, Aldosterone being just one of them. (We study and research hormonal actions and use them in therapeutic doses in the regiment)

There are some Neuro-Abnormalities which may be addressed with potassium dosing. These symptoms are mostly related to either motor or sensory nerves and the lack of or de-stabilization of transmission responses. These would include the Feet, Legs, Arms or Hands, which would experience a loss of feeling, numbness, or a tingling sensation. These are all signs of possible potassium deficiency that may be treated with positive results by starting the patient on an optimum dose of Potassium.

Muscular weakness, Muscular fatigue, Muscular lethargy is another age related health problem that can see improvement with the use of Potassium. Because of it’s ability to assist in the proper contraction and proper expansion of neurological commands issued to the muscular tissue, it greatly increases the lost efficiency which has been degenerating over a period of time. The muscular tissue groups in which the nerve messages are being sent are not functioning properly. They are getting only a limited amount of command messages. Between the enhancement to muscular tissue itself and the improvement to the nervous systems transmission regulation, the above problems show improvement with the use of daily potassium and daily exercise.

At this time we would not advise over 300 mg of element Potassium spread out throughout the day divide in equal doses. The amount of Potassium absorbed by older or aged patients is much less than young adults, because their absordability rate can be anywhere from 60% to 85% less than that of a 22 year old. This is why the amount of ingested potassium that actually passes though the small intestinal wall and then is finally on its way to the liver, decrease greatly with age. This explains clearly why older patients have cardiovascular circulatory inflammatory problems, the muscular lethargy and muscular weakness problems, and the physiological and anatomy nervous system degeneration problems. And this is true for all Minerals, Enzymes, Amino Acids and the patients Hormonal Production. It has all fallen off from the 22-year-old levels. Patients with Kidney Disease, Type 1 Diabetes, and those on nonsteriodal anti-inflammatory drugs, Heart medication like "Heparin" and ACE inhibitors, and potassium sparing diuretics, should be watched and their doses monitored very closely by a doctor when starting to use Potassium. Diuretics assist in helping the body get rid of excess water, but it will also deplete your potassium levels at the same time. The heart medication "Digitalis" will also cause you to reduce and deplete the body's biochemical potassium levels. This in time causes additional problems, which we address in this report.

Please note the Hormonal/Endocrine pathway inside the Kidneys with regards to low blood pressure; the first response is for the Kidneys to form "Renin". It is produce in direct response to lowered blood pressure inside the body. Or what the body thinks is too low blood pressure. At the time of detection of low blood pressure, inside the kidneys, Renin is secreted; it moves forward on its own biochemical pathway and combines with the patient’s blood to form "Angiotensin". Now when Angiotensin is formed, it’s reaction stimulates the production of the steroid hormone "Aldosterone", which is a mineral-cortico-steroid produced by the adrenal cortex. But when this hormone is produce and release it has the effect of increasing sodium reabsorption inside the Kidneys. Which then raises the blood pressure. The Sodium levels stay in, and thus blood pressure stays high and any beneficial health effects, which the body really needs, can’t be acquired. This is what we see as common in age related disease. Potassium helps and assists in reducing blood pressure and getting the patients response cycle back closer to a "normal state". The cycle as explained here is a hormonal response, which is being assisted and counter balanced for correction by Potassium. The problem is that in the human body, after early /mid forty’s and upwards, hypertension usually starts to develop. The hypertension which we see in common middle aged and older patients is really a dysfunctional kidney hormonal endocrine system which is aging and is no longer functioning anywhere close to it’s original normal design, let say between 22 – 25 years of age. The degeneration processing is already setting in and we all know that high blood pressure kills, slowly but surely over the years it does it’s internal damage.

Potassium also acts upon and has a biochemical interface with the hormones Antidiuretic (ADH) [also called Vasopressin] and Norepinephrine. These hormones are produced by the pituitary gland, the posterior lobe section, and they have a direct reaction on the kidneys to increase the reabsorption of water. Potassium brings about enhancement support again in counter-balancing these pituitary hormones and having them slow down their biochemical command signals to the kidneys. This Potassium/Hormonal interface which is always going on and is being played out on the biochemical physiology stage of the body is of the up most importance for normal kidney, correct discharge of toxins and proper blood pressure levels. They are highly related to each other which when combined inside the body, in the proper ratios cause positive excitable biochemical actions and reactions to happen. These reactions are happening along these pathways 24 hours a day. When they are not functioning in the proper format, the patient develops a multitude of directly related problems because this process is in partial or full failure mode.

We have witnessed and can verify these results from our Medical Trials. More information to be added in the future based on additional information we gain from our on going medical trials.

Best Regards – Tim Cochran

Therapeutic Biochemist